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Panama Canal Cruises - Top Picks

This week, Cruise1st’s Top Picks spotlight the enchanting Panama Canal cruises, where you can delve into stunning landscapes and vibrant cultures. Experience the bustling charm of Colon, where the iconic Miraflores Locks reveal the engineering marvel of the Canal. Don’t miss a visit to the lush wonders of Gatun Lake, teeming with wildlife. Explore the historical allure of Panama City with its picturesque Casco Viejo district, filled with colourful colonial architecture. These trending adventures promise unforgettable memories among breathtaking vistas!

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Panama Canal Cruises - Top Picks

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Central America from Colón, Panama with the Serenade of the Seas

Royal Caribbean

Central America from Colón, Panama with the Serenade of the Seas

10 nights

From Colón to Los Angeles

Serenade of the Seas

25/04/2026 - 05/05/2026

Cruise

Inside

from £968 pp

Outside

from £1,216 pp

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Luxury Panama Canal and Southern Caribbean

Cruise1st Package

Luxury Panama Canal and Southern Caribbean

15 nights

From Fort Lauderdale to Fort Lauderdale

Celebrity Ascent

20/11/2026 - 05/12/2026

Cruise

Flight

Hotel

All Inclusive

Inside

from £3,599 pp

Outside

from £3,749 pp