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Panama City Cruises

Cruise to Panama City with Cruise1st and enjoy unparalleled luxury, top-notch amenities, and exclusive deals. Book your dream cruise today!

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CRUISE1ST Package

All Inclusive South & Central America, Mexico and USA

All Inclusive South & Central America, Mexico and USA

24 nights

From Miami to Seattle

Norwegian Encore

10/04/2026 - 04/05/2026

Cruise

Flight

Hotel

Inside

from £3,699 pp

Outside

from £4,499 pp

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CRUISE1ST Package

All Inclusive Machu Picchu, Lake Titicaca & Luxury South America Cruising

23 nights

From Miami to Callao (Lima)

Norwegian Jade

26/02/2026 - 21/03/2026

Cruise

Flight

Train

Hotel

Tour

Inside

from £5,199 pp

Outside

from £5,599 pp

CRUISE1ST Package

All Inclusive South & Central America and Mexico

19 nights

From Callao (Lima) to San Diego

Norwegian Jade

10/03/2026 - 29/03/2026

Cruise

Flight

Hotel

Inside

from £3,399 pp

Outside

from £3,899 pp

CRUISE1ST Package

Luxury Central America Tapestry (Miami to Lima) with Miami Stay

17 nights

From Miami to Callao (Lima)

Azamara Onward

04/01/2026 - 21/01/2026

Cruise

Flight

Hotel

All Inclusive

Drinks

Tips

Inside

from £5,799 pp

Outside

from £6,499 pp

Central America from San Diego, California with the Norwegian Jade

Central America from San Diego, California with the Norwegian Jade

15 nights

From San Diego to Miami

Norwegian Jade

12/02/2026 - 27/02/2026

Cruise

Inside

from £2,045 pp

Outside

from £2,390 pp

South America from Miami, Florida with the Norwegian Jade

12 nights

From Miami to Callao (Lima)

Norwegian Jade

27/02/2026 - 11/03/2026

Cruise

Inside

from £2,485 pp

Outside

from £3,205 pp

South America from San Antonio, Chile with the Azamara Quest

13 nights

From San Antonio to Panama City

Azamara Quest

02/03/2026 - 15/03/2026

Cruise

All Inclusive

Drinks

Tips

Inside

from £3,381 pp

£4,449

Outside

from £3,704 pp

£4,874

South America from Miami, Florida with the Azamara Onward

15 nights

From Miami to Callao (Lima)

Azamara Onward

06/01/2026 - 21/01/2026

Cruise

All Inclusive

Drinks

Tips

Inside

from £4,711 pp

£4,959

Outside

from £5,338 pp

£5,619

CRUISE1ST Package

All Inclusive USA to Peru with Panama Canal Transit

15 nights

From Miami to Callao (Lima)

Norwegian Jade

25/02/2026 - 12/03/2026

Cruise

Flight

Hotel

Inside

from £3,099 pp

Outside

from £3,399 pp

CRUISE1ST Package

Central America Tapestry Luxury Cruise Followed by a Machu Picchu & Sacred Valley Tour

22 nights

From Miami to Callao (Lima)

Azamara Onward

05/01/2026 - 27/01/2026

Cruise

Flight

Hotel

Tour

All Inclusive

Drinks

Tips

Inside

from £7,499 pp

Outside

from £8,099 pp

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